1.7mg semaglutide Semgo 7mg (Semaglutide) – Tablets for Diabetes & Weight Loss When semaglutide is injected with the Wegovy injector Oral GLP-1 Receptor Agonist |

This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier

There is a fiscal-rule scoring problem behind this

It's not just about what you're losing on the scale

Going slower is always acceptable